Thalidomide-induced sensory axonal polyneuropathy: A case report

Introduction: Several chemotherapeutic agents are currently available for the management of various malignancies; however, many associated with adverse effects. A case thalidomide- induced polyneuropathy is described below. Case Description: 65year old man, a history secondary myelofibrosis in thalidomide, consulted 5months neuropathic pain and paresthesia both hands. On physical examination, he presented hypoesthesia hyperalgesia In electrodiagnostic studies (EDX) sensory axonal type was concluded. Discussion: Chemotherapy-induced peripheral neuropathy (CIPN) side effect that occurs up to 70% patients. Symptomatology includes motor sensitive deficit. EDX confirm diagnoses characteristics. For particular thalidomide involvement mainly axonal. There no standard treatment CIPN, but several drugs can improve symptoms. Conclusions: CIPN frequent complication patients managed chemotherapy. The physiatrist ideal professional provide comprehensive approach this entity, order patient’s functionality.